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KMID : 0391520060140020358
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Journal of the Korean Child Neurology Society
2006 Volume.14 No. 2 p.358 ~ p.362
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A Case of Acute Isoniazid Intoxication in Childhood.
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Kook Dong-Hyuk
Cho Sun-Young
Lee Kyung-Yil
Lee In-Goo
Lee Joon-Sung
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Abstract
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Acute isoniazid overdose is a relatively uncommon but potentially life-threatening event. Isoniazid overdose should be suspected in any patient with repeated seizures, coma and metabolic acidosis of uncertain etiology. The effective antidote for acute isoniazid- induced neurotoxicity is known to be pyridoxine. We report a 4-month old boy who showed repeated seizures, coma, metabolic acidosis and hyperglycemia from an accidental isoniazid overdose(100 mg/kg). This boy was recovered completely by the pyridoxine treatment with a dose of equivalent to the amount of isoniazid ingested.
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KEYWORD
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Isoniazid, Intoxication, Child
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